First off, we have a discussion thread open on these new NVIDIA drivers right here.

New in Version 196.21

• Adds SLI and multi-GPU support for many top new gaming titles including Avatar Demo, Battlefield: Bad Company 2, City Bus Simulator, Dirt 2, Ferrari Virtual Race, GREED: Black Border, Mass Effect 2, Mortal Online, Ninja Blade, Operation Flashpoint: Dragon Rising Demo, Planet 51, RUSE, Serious Sam HD, and Wings of Prey.
• Upgrades PhysX System Software to version 9.09.1112.
• Includes numerous bug fixes. Refer to the release notes on the documentation tab for information about the key bug fixes in this release.

Existing Support:

• Supports GPU-acceleration for smoother online HD videos with the new Adobe Flash 10.1 beta. Learn more here. 
• Supports DirectCompute with Windows 7 and GeForce 8-series and later GPUs.
• Supports OpenCL 1.0 (Open Computing Language) for all GeForce 8-series and later GPUs.
• Supports OpenGL 3.2 for GeForce 8-series and later GPUs.
• Supports CUDA Toolkit 3.0 features and performance enhancements. See CUDA Zone for more details.
• Supports NVIDIA 3D Vision Discover, a complete, low cost solution to start your immersive stereoscopic 3D experience. NOTE: If you are using NVIDIA 3D Vision active shutter glasses, you must download the separate 3D Vision driver which includes the driver for the 3D Vision IR emitter.
• Supports single GPU and NVIDIA SLI technology on DirectX 9, DirectX 10, and OpenGL, including 3-way SLI, Quad SLI, and SLI support on SLI-certified Intel X58-based motherboards.
• Supports NVIDIA PhysX acceleration on a dedicated GeForce graphics card. Use one card for graphics and dedicate a different card for PhysX processing for game-changing physical effects. This driver installs PhysX System Software version 9.09.1112. Learn more here.
• Download these FREE PhysX and CUDA applications now!
• Supports GPU overclocking and temperature monitoring by installing NVIDIA System Tools software.
• Release Notes (v196.21)
• Control Panel User's Guide

GeForce 200 series:
GTX 285, 205, GT 240, GT 230, GTX 280, GTS 250, G210, GTX 275, GTX 295, 210, GT 220, GTX 260, GTS 240

GeForce 100 series:
GT 130, G 100, GT 120, GT 140

GeForce 9 series:
9500 GS, 9600 GT, 9200, 9800 GX2, 9500 GT, 9600 GS, 9300, 9800 GT, 9400 GT, 9300 GS, 9400, 9600 GSO, 9300 GE, 9800 GTX/GTX+

GeForce 8 series:
8400, 8800 GT, 8100 / nForce 720a, 8300 GS, 8600 GT, 8800 Ultra, 8800 GTS 512, 8800 GS, 8500 GT, 8600 GS, 8800 GTS, 8800 GTX, 8200, 8400 GS, 8300, 8600 GTS, 8400 SE

GeForce 7 series:
7900 GS, 7050 / NVIDIA nForce 630i, 7900 GTX, 7800 GTX, 7600 LE, 7900 GT/GTO, 7300 GT, 7950 GT, 7300 SE / 7200 GS, 7300 GS, 7350 LE, 7050 PV / NVIDIA nForce 630a, 7300 LE, 7025 / NVIDIA nForce 630a, 7500 LE, 7650 GS, 7100 GS, 7100 / NVIDIA nForce 630i, 7050 / NVIDIA nForce 610i, 7800 SLI, 7150 / NVIDIA nForce 630i, 7950 GX2, 7800 GS, 7600 GT, 7600 GS, 7550 LE, 7100 / NVIDIA nForce 620i

GeForce 6 series:
6800 GT, 6610 XL, 6800 XT, 6800 XE, 6700 XL, 6150 LE, 6150LE / Quadro NVS 210S, 6800 GS, 6150, 6800 GS/XT, 6100 nForce 400, 6800, 6600 LE, 6200SE TurboCache, 6800 LE, 6100, 6600, 6800 Ultra, 6200 LE, 6100 nForce 420, 6200 TurboCache, 6200 A-LE, 6200, 6150SE nForce 430, 6250, 6100 nForce 405, 6600 GT, 6500, 6600 VE

ION series:
ION LE, ION

Have you read our GF100 (Fermi) technology preview already ?